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Stem Cells and Nanoparticles in Therapy

Author(s):

Viteri Marco*, Toscano Fernanda*, Gavilanes Alex, Torres Arias Marbel and Seqqat Rachid   Pages 1 - 18 ( 18 )

Abstract:


The application of nanotechnology to stem cell research and development has made great strides during the last years. Nanotechnology offers a new opportunity for research and development of stem cells. The mammary gland is a dynamic organ that undergoes extensive morphogenesis during the different stages of embryonic development, puberty, pregnancy, lactation and involution. There are multipotent stem cells that reside in mammary tissue (MaSCs) with the ability to self-renew and even differentiate into all types of mammary cells. To identify, characterize, and differentiate MaSCs, a variety of methods have been used to understand the signal transduction pathways that promote their self-renewal and their cellular fate. In the last decade, stem cell therapy has become a promising and modern topic of scientific research, which has raised great expectations. However, by itself, it presents some problems that have been overcome with the use of nanoparticles (NPs). A triple function has been accomplished: transport of drugs or biomolecules that help in the differentiation and proliferation of stem cells, cell targeting and contrast agents for real-time monitoring and obtaining bioimages for diagnostic and detection systems. The main objective of applying stem cells in conjunction with NPs is to control cellular activity, mainly the regenerative capacity of mammary tissue against diseases such as mastitis or to optimize milk production. In this review, we provide a current overview of the application of nanomaterials on stem cells, specifically bovine stem cells in both the mammary gland and milk, as they are a potential source of cell progenitors with potential characteristics and could be used in potential therapies based on with these cells.

Keywords:

Stem cells, nanotechnology, bovine mammary stem cells, milk stem cells, nanoparticles

Affiliation:

Departamento de Ciencias de la Vida, Laboratorio de Inmunología y Virología, Universidad de las Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, P.O. Box 171-5-231B, Sangolquí, Departamento de Ciencias de la Vida, Laboratorio de Inmunología y Virología, Universidad de las Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, P.O. Box 171-5-231B, Sangolquí, Departamento de Ciencias de la Vida, Laboratorio de Inmunología y Virología, Universidad de las Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, P.O. Box 171-5-231B, Sangolquí, Departamento de Ciencias de la Vida, Laboratorio de Inmunología y Virología, Universidad de las Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, P.O. Box 171-5-231B, Sangolquí, Departamento de Ciencias de la Vida, Laboratorio de Inmunología y Virología, Universidad de las Fuerzas Armadas ESPE, Av. Gral. Rumiñahui s/n, P.O. Box 171-5-231B, Sangolquí



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