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Mesoporous Silica Nanoparticles of Hydroxyurea: Potentially Active Therapeutic Agents

[ Vol. 11 , Issue. 2 ]

Author(s):

Kumar Nishchaya*, Swatantra K.S. Kushwaha and Awani K. Rai   Pages 211 - 223 ( 13 )

Abstract:


Background: Present malignant cancer medicines have the advantage of magnetic nanoparticles as delivery carriers to magnetically accumulate anticancer medication in malignant growth tissue.

Aim: In the present investigation, silica nanoparticles (MSNs) stacked with hydroxyurea were combined and optimized for dependent and independent variables.

Methods: In this study, microporous silica nanoparticles stacked with neoplastic medication were prepared through emulsification followed by the solvent evaporation method. Prepared MSNs were optimized for dependent and independent variables. Different formulations were prepared with varying ratios of polymer, lipid and surfactant which affect drug release and kinetics of drug release pattern. The obtained MSNs were identified by FTIR, SEM, drug entrapment, in-vitro drug release, drug release kinetics study, and stability testing in order to investigate the nanoparticle characteristics.

Results: The percentage drug entrapment of the drug for the formulations F1, F2, F3 was found to be 27.78%, 65.52% and 48.26%. The average particle size for F2 formulation was found to be 520 nm through SEM. The cumulative drug release for the formulations F1, F2, F3 was found to be 64.17%, 71.82% and 32.68%. The formulations were found to be stable which gives controlled drug delivery for 6 hours.

Conclusion: From the stability studies data, it can be concluded that formulations are most stable when stored at a lower temperature or in a refrigerator, i.e. 5°C ± 3°C. It can be concluded that MSNs loaded with hydroxyurea is a promising approach towards the management of cancer due to sustained release and few side effects.

Keywords:

MSNs, solvent evaporation, kinetics, SEM, hydroxyurea, ribonucleotide reductase.

Affiliation:

Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305, Department of Pharmacy, Pranveer Singh Institute of Technology, Kanpur-209305

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