Alaa A. A. Aljabali* and Mohammad A. Obeid Pages 1 - 18 ( 18 )
Background: Surface modification of nanoparticles with targeting moieties can be achieved through bioconjugation chemistries to impart new targeted moieties. Various polymeric nanoparticles have been used for the formulation of nanoparticles such as naturally-occurring protein cages, virus-like particles, polymeric saccharides, and liposomes. These polymers have been proven to be biocompatible, side effects free and degradable with no toxicity.Objectives: This paper reviews available literature on the nanoparticles pharmaceutical and medical applications. The review highlights and updates the customized solutions for selective drug delivery systems that allow high-affinity binding between nanoparticles and the target receptors. Methods: Bibliographic databases and web-search engines were used to retrieve studies that assessed the usability of nanoparticles in the pharmaceutical and medical fields. Data were extracted on each system. in Vivo and in Vitro applications, its advantages and disadvantages, and its ability to be chemically and genetically modified to impart new functionalities. Finally, a comparison between naturally occurring and their synthetic counterparts was carried out. Results: The results showed that nanoparticles-based systems could have promising applications in diagnostics, cell labeling, contrast agents (Magnetic Resonance Imaging and Computed Tomography), antimicrobial agents, and as drug delivery systems. However, precautions should be taken to avoid or minimize toxic effect or incompatibility of nanoparticles-based systems with the biological systems in case of pharmaceutical or medical applications. Conclusion: This review presented a summary of recent developments in the field of pharmaceutical nanotechnology and highlighted the challenges and the merits that some of the nanoparticlesbased systems both in vivo and in vitro systems.
Nanoengineering; drug delivery; viruses; tumor targeting; imaging; pharmaceutical nanotechnology.
Faculty of Pharmacy, Department of Pharmaceutical Sciences.Yarmouk University, P.O. BOX 566, Irbid 21163, Faculty of Pharmacy, Department of Pharmaceutical Sciences.Yarmouk University, P.O. BOX 566, Irbid 21163