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CdSe Quantum Dots Induce Cellular Differentiation in HL-60 Cells

[ Vol. 10 , Issue. 2 ]

Author(s):

Amit D. Saran* and Jayesh R. Bellare   Pages 175 - 183 ( 9 )

Abstract:


Background: CdSe QDs, synthesized using a green micro-emulsion method, have been evaluated for their potential in inducing HL-60 differentiation by employing various biochemical assays and as cellular imaging agents.

Methods: CdSe QDs have been found to effectively induce differentiation with lower rate of cell apoptosis as compared with the positive control (DMSO).

Results: Our results exhibit effective induction of HL-60 differentiation by CdSe QDs implicating their therapeutic role in cancerous cells in addition to their usual application as cell-imaging agents.

Conclusion: Our studies report that the chemo-preventive properties of CdSe exhibit great potential and further tailored-synthesis and cell-differen-tiations studies have a promising future in the preventive treatment of HL60 cancerous tissue.

Keywords:

CdSe, quantum dots, microemulsion, HL60, cell differentiation, cell death, nanomedicine.

Affiliation:

Department of Chemical Engineering, Dr. B.R. Ambedkar National Institute of Technology, Jalandhar 144011, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076

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