Amit D. Saran* and Jayesh R. Bellare Pages 175 - 183 ( 9 )
Background: CdSe QDs, synthesized using a green micro-emulsion method, have been evaluated for their potential in inducing HL-60 differentiation by employing various biochemical assays and as cellular imaging agents.
Methods: CdSe QDs have been found to effectively induce differentiation with lower rate of cell apoptosis as compared with the positive control (DMSO).
Results: Our results exhibit effective induction of HL-60 differentiation by CdSe QDs implicating their therapeutic role in cancerous cells in addition to their usual application as cell-imaging agents.
Conclusion: Our studies report that the chemo-preventive properties of CdSe exhibit great potential and further tailored-synthesis and cell-differen-tiations studies have a promising future in the preventive treatment of HL60 cancerous tissue.
CdSe, quantum dots, microemulsion, HL60, cell differentiation, cell death, nanomedicine.
Department of Chemical Engineering, Dr. B.R. Ambedkar National Institute of Technology, Jalandhar 144011, School of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Mumbai 400 076