Keerti Jain* Pages 21 - 29 ( 9 )
Introduction: Nanomaterials are emerging as a fascinating delivery systems being explored for the delivery of different bioactives including drug, diagnostic agents and genetic materials etc. Among these nanomaterials dendrimers and Carbon Nanotubes (CNTs) are being investigated for various biomedical applications. Although both of these nanomaterials have shown great potential in drug delivery yet their promising clinical applications are still suspected due to problems like toxicity, dispersibility etc. Scientists have been investigating the potential of nanohybrids comprising of dendrimers and nanotubes for biomedical applications. Few reports are also available on the toxicological profile of CNTs and dendrimers nanohybrids.
Conclusion: The results of these investigations suggest two possibilities, first, hybrids of CNTs and dendrimers could suppress each other’s demerits while synergizing the potentials; second, prospective toxicity of nanohybrids on which different reports have discrimination in results. Future biomedical applications of CNTs-dendrimers nanohybrids require a thorough investigation on their toxicity and biological interactions.
Dendrimers, carbon nanotubes, drug delivery, nanohybrids, toxicity, nanomaterials.
National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, U.P