B. S. Unnikrishnan, Manu M. Joseph, G. U. Preethi, R. Shiji and T. T. Sreelekha Pages 26 - 40 ( 15 )
Nanotechnology plays a prominent role virtually in every field of science and technology, especially in the drug delivery systems. Nanoparticles (NPs) possess unique advantages over the existing strategies prevailed in biomedical applications but, they face certain challenges including its synthesis from expensive synthetic routes and use of toxic reagents. Till date, most of the approaches focused on the synthesis of NPs from nonbiological sources and its application is limited due to its toxicity and instability in biological systems. Biogenic NPs paved a ray of hope in the establishment of a new era with ecofriendly nanoparticles in medical sciences particularly in drug delivery, bio-imaging and other therapeutic approaches. The preparation of NPs using biological materials is described under “green chemistry” approach; which is a philosophy of chemical research and engineering that encourages the design of products and processes that minimize the use and generation of hazardous substances through smarter production. Past decade saw a large number of significant developments with the application of biogenic NPs in the field of oncology. Various materials of biological origin offer unique promising features to tailor biogenic NPs with predefined properties. The current review describes about the recent developments in the synthesis and significance of biogenic NPs in the management of various clinical abnormalities especially cancer. By drawing diverse toolset for generation of NPs from inexpensive biological source, this article exploits high impact application of these NPs in biomedical field.
Biomedical applications, cancer, chitosan, green synthesis, nanoparticles.
Division of Cancer Research, Regional Cancer Centre, Trivandrum, Kerala-695011