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In-vitro Characterization of Chitosan Nanoparticles of Fluconazole as a Carrier for Sustained Ocular Delivery

[ Vol. 7 , Issue. 1 ]

Author(s):

Kumaraswamy Santhi, Selvadurai Muralidharan, Young H. Yee, Fong Y. Min, Chong Z. Ting and Durga Devi   Pages 41 - 50 ( 10 )

Abstract:


The aim of the present study is to develop and formulate a nanoparticulate carrier for sustained and ocular delivery of Fluconazole and to study its in-vitro release characters. Chitosan nanoparticles of Fluconazole were formulated by spontaneous emulsification and cross-linking method. The mean particle size, drug loading capacity, invitro release profile and release kinetics were studied. The antifungal efficacies of nanospheres were compared with conventional eye drops by cup-plate method. The average particle size was found to be 152.85±13.7nm. The drug loading capacity of all drug loaded nanoparticles was found to be optimum (≤50%). The in-vitro release study revealed the zero order kinetics and Higuchi’s diffusion mechanism. The drug bound nanoparticles exhibited good in-vitro antifungal effect in comparison with conventional eye drops. The formulated nanoparticles were found to be a suitable carrier for sustained ocular delivery of Fluconazole in terms of optimum drug loading, sustained release characters and antifungal activity.

Keywords:

Chitosan, fluconazole, nanoparticles, ocular, sustained release.

Affiliation:

Faculty of Pharmacy, Semeling-08100, Bedong, Kedah, Pharmaceutical Chemistry Unit, Faculty of Pharmacy, AIMST University, Semeling, Kedah, Pharmaceutics Unit, Faculty of Pharmacy, AIMST University, Semeling, Kedah, Pharmaceutics Unit, Faculty of Pharmacy, AIMST University, Semeling, Kedah, Pharmaceutics Unit, Faculty of Pharmacy, AIMST University, Semeling, Kedah, Pharmaceutics Unit, Faculty of Pharmacy, AIMST University, Semeling, Kedah



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