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Solid Lipid Nanoparticles: An Innovative Nano-Vehicles for Drug Delivery

[ Vol. 4 , Issue. 1 ]

Author(s):

Hema Chaudhary, Samita, Nitika Puri and Vikash Kumar   Pages 38 - 44 ( 7 )

Abstract:


Nanotechnology is an emergent field with numerous applications in drug delivery, clinical medicine, nutriceuticals as well as in other fields also. In this techno, Solid lipid nanoparticles (SLN) is a part which consist solid colloidal particles ranging in size from 1 to 1000 nm and act as “magic bullet” when coupled with ligands/targeting ligands. SLN consisting of a solid-lipid promising advance delivery of lipophilic drugs and also used as an alternate for conventional carriers such as micro-emulsions, liposomes and nanoparticles based on natural/synthetic polymers. They are formulated from synthetic/natural lipids and optimize the drug delivery to provide a protection to sensitive drugs and obtain better/improve bioavailability with less toxicity (as compared to polymeric NPs) due to its biodegradable/bioacceptable nature. Moreover, Surface Modified SLNs is a new promising approach for protein loading and antigen delivery system.

Keywords:

Nanotechnology, solid lipid nanoparticles (SLN), drug delivery, toxicity.

Affiliation:

PDM College of Pharmacy, Bahadurgarh, Haryana, India.



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